Multifunctional hydrogels based on ß-cyclodextrin with both biomineralization and anti-inflammatory properties.

Carbohydrate polymers

PubMedID: 24507358

Liu S, Chen X, Zhang Q, Wu W, Xin J, Li J. Multifunctional hydrogels based on ß-cyclodextrin with both biomineralization and anti-inflammatory properties. Carbohydr Polym. 2014;102869-76.
In this study, a series of carboxylated hydrogels are synthesized using ß-cyclodextrin, epichlorohydrin and succinic anhydride. It is found that the carboxyl groups on the ß-cyclodextrin hydrogels could facilitate the biomineralization process in the simulated body fluid. The new generated minerals are apatite and similar to that of bones. Meanwhile, the carboxylated ß-cyclodextrin hydrogels can also load and release anti-inflammatory drug (using indomethacin as a model) in a controlled manner during the biomineralization process for 28 days. The carboxylated ß-cyclodextrin hydrogels also have low cytotoxicity and are promising for bone tissue engineering.