Preliminary Study of the Association of White-Matter Metabolite Concentrations With Disease Severity in Patients With Huntington's Disease.

The Journal of neuropsychiatry and clinical neurosciences

PubMedID: 24515683

Yager JR, Gasparovic C, Magnotta VA, Adams W, Fiedorowicz J, Paulsen J, Jorge R, Beglinger LJ. Preliminary Study of the Association of White-Matter Metabolite Concentrations With Disease Severity in Patients With Huntington's Disease. J Neuropsychiatry Clin Neurosci. 2014;26(1):101-4.
Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington's disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.