Prazosin for Military Combat-Related PTSD Nightmares: A Critical Review.

The Journal of neuropsychiatry and clinical neurosciences

PubMedID: 24515675

Writer BW, Meyer EG, Schillerstrom JE. Prazosin for Military Combat-Related PTSD Nightmares: A Critical Review. J Neuropsychiatry Clin Neurosci. 2014;26(1):24-33.
Military combat is a common trauma experience associated with posttraumatic stress disorder (PTSD). Trauma-related nightmares are a hallmark symptom of PTSD. They can be resistant to label-pharmacological PTSD treatment, and they are associated with a variety of adverse health outcomes. The purpose of this article is to review and evaluate prazosin therapy for combat-related PTSD nightmares. Consistent with available literature for all-causes PTSD nightmares, prazosin is an effective off-label option for combat-related PTSD nightmares. Future trials may further instruct use in specific combat-exposure profiles.