Targeting the pancreatic ß-cell to treat diabetes.

Nature reviews. Drug discovery

PubMedID: 24525781

Vetere A, Choudhary A, Burns SM, Wagner BK. Targeting the pancreatic ß-cell to treat diabetes. Nat Rev Drug Discov. 2014;.
Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect over 500 million people by 2030. However, this growing burden of disease has not been met with a comparable expansion in therapeutic options. The appreciation of the pancreatic ß-cell as a central player in the pathogenesis of both type 1 and type 2 diabetes has renewed focus on ways to improve glucose homeostasis by preserving, expanding and improving the function of this key cell type. Here, we provide an overview of the latest developments in this field, with an emphasis on the most promising strategies identified to date for treating diabetes by targeting the ß-cell.