Switch of cadherin expression as a diagnostic tool for Leydig cell tumours.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

PubMedID: 23398382

F B, S S, M MO, B H, A S, Hj R, Cl B. Switch of cadherin expression as a diagnostic tool for Leydig cell tumours. APMIS. 2013;.
Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis with Leydig cell hyperplasia and Leydig cell tumours for their expression pattern of P- and N-cadherin. We could show a switch of expression of P- and N-cadherin in Leydig cell hyperplasia and Leydig cell tumours in comparison with normal Leydig cells. Cadherins could be established as a new immunohistochemical marker for this testicular tumour entity; their possible role in tumour genesis will be discussed.