Prognostic value of biological markers in myocardial infarction patients.

Asian cardiovascular & thoracic annals

PubMedID: 24532611

Berezin AE, Samura TA. Prognostic value of biological markers in myocardial infarction patients. Asian Cardiovasc Thorac Ann. 2013;21(2):142-50.
Objective: The aim of this study was to compare the prognostic value of matrix metalloproteinase-3 and -9, and NT-pro-natriuretic peptide for fatal and nonfatal complications in Q-wave myocardial infarction patients in the acute and postinfarction periods. Patients and methods: 85 men and women with documented Q-wave myocardial infarction were observed for 1 year after hospitalization. Clinical endpoints were identified through the hospital patient-tracking system, with a review of medical records for each recorded endpoint. Left ventricular ejection fraction and wall motion index were calculated. Measurements of matrix metalloproteinases and NT-pro-natriuretic peptide were performed by an enzyme-linked immunosorbent assay. Results: A cutoff value of 9.7?ng·mL(-1) for matrix metalloproteinase-3 showed the best discriminatory power (sensitivity?=?77.8%, specificity?=?90.8%). The optimal cutoff value of matrix metalloproteinase-9 was 18.1?ng·mL(-1) (sensitivity, 70.5%; specificity, 75%), and the cutoff for NT-pro-natriuretic peptide was 885?pmol·L(-1) (sensitivity, 58%; specificity, 68.6%). Matrix metalloproteinase-3 and -9 were strongly related with a positive prognostic value of 70% (sensitivity and specificity, 84% and 82%, respectively). Conclusion: These data may be helpful for further stratification of patients into cardiovascular mortality risk groups.