Are Increased Levels of Systemic Oxidative Stress and Inflammation Associated with Age-Related Cataract?

Antioxidants & redox signaling

PubMedID: 24527727

Selin JZ, Lindblad BE, Rautiainen S, Michaƫlsson K, Morgenstern R, Bottai M, Basu S, Wolk A. Are Increased Levels of Systemic Oxidative Stress and Inflammation Associated with Age-Related Cataract?. Antioxid Redox Signal. 2014;.
Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F2a (as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-prostaglandin F2a (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection, that women with higher levels of urinary 8-iso-prostaglandin F2a as compared to lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF2a levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.