[Relationship of IFRD1-rs3807213 gene polymorphism with the risk of gastric cancer among Chinese].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

PubMedID: 24527581

Peng CB, Xu R, Xiao SM, Zhuang W. [Relationship of IFRD1-rs3807213 gene polymorphism with the risk of gastric cancer among Chinese]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2014;45(1):49-52.
OBJECTIVE
To investigate the association between rs3807213 gene polymorphism in interferon related developmental regulator 1 gene (IFRD1) and the risk of gastric cancer among Chinese.

METHODS
There were 53 gastric cancer patients and 50 healthy people included in this case-control study. The blood samples were collected from each observed object and genotype (AA, AC, CC) of IFRD1 rs3807213 SNP was detected after polymerase chain reaction (PCR). The relationships of rs3807213 gene polymorphism with gastric cancer risk, clinic and pathologic features were analyzed.

RESULTS
Patients with stomach cancer had a significantly higher frequency of rs3807213 C allele distributions (OR = 3.759, 95% CI = 1.521-9.294; P = 0.003) than the controls. Compared with control group, patients with gastric cancer had a significantly higher frequency of rs3807213 CC genotype (OR = 4.028, 95% CI = 1.513-10.720; P = 0.004). When stratified by pathological stage of gastric cancer, there was no significant difference observed.

CONCLUSION
IFRD1-rs3807213 polymorphism may be associated with the increased risk of gastric cancer.