Detailed in utero ultrasound description of 30 cases of congenital cytomegalovirus infection.

Prenatal diagnosis

PubMedID: 24532345

Picone O, Teissier N, Cordier AG, Vauloup-Fellous C, Adle-Biassette H, Martinovic J, Senat MV, Ayoubi JM, Benachi A. Detailed in utero ultrasound description of 30 cases of congenital cytomegalovirus infection. Prenat Diagn. 2014;.
OBJECTIVES
To describe precisely prenatal ultrasound features in congenital cytomegalovirus (CMV) infection.

METHODS
We retrospectively evaluated the ultrasound descriptions of cases of congenital CMV infection between 2004 and 2013.

RESULTS
In 69 congenital CMV infections, related ultrasound abnormalities were reported in 30 cases (43.5%). There were both extracerebral and cerebral abnormalities in 16 cases, purely abnormal brain features in 10, and purely extracerebral features in 2. 19/30 cases presented extracerebral features of 11 different sorts of abnormalities, mainly hyperechogenic bowel (10 cases) and intrauterine growth retardation (9 cases). 24/30 cases presented cerebral features of 13 different sorts, mainly brain calcifications (12 cases) and occipital horn cavity (11 cases). The main ultrasound findings in our series are not specific to CMV infection. However, a frequent finding attracted our attention: the anechogenic cavity located on the extremity of the occipital horn, a region which contains numerous proliferating and differentiating germinal cells.

CONCLUSIONS
By improving knowledge of ultrasound findings linked to CMV infection, ultrasound sensitivity may be improved. Understanding why CMV leads to lesions of the occipital horn may help clarify the pathophysiology of congenital infection. This article is protected by copyright. All rights reserved.