Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum.

Fitoterapia

PubMedID: 24534445

Xiong J, Liu XH, Bui VB, Hong ZL, Wang LJ, Zhao Y, Fan H, Yang GX, Hu JF. Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum. Fitoterapia. 2014;.
One (formosumone A, 1) new and fifteen (2-16) known phenolic compounds were isolated from the leaves of Cratoxylum formosum ssp. pruniflorumm, a substitute for the popular bitter nail tea ("Kuding Tea") generally used in Southeast Asia. Their structures were determined by extensive spectroscopic analysis and by comparison with literature data. Compound 1 possesses a rare scaffold of a flavanone coupled with a phloroglucinol moiety, representing the first example of such a scaffold from the Clusiaceae family. Among the isolates, toxyloxanthone B (11) and vismione D (12) were found to show remarkable anti-neuroinflammatory effects by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells. Additionally, toxyloxanthone B (11) exhibtied significant neuroprotective effect against ß-amyloid25-35 (Aß25-35)-induced cell viability decrease in SH-SY5Y neuroblastoma cells.