Palladium(0)-catalyzed cyclopropanation of benzyl bromides via C(sp(3))-H bond activation.

Chemical communications (Cambridge, England)

PubMedID: 24575427

Mao J, Zhang SQ, Shi BF, Bao W. Palladium(0)-catalyzed cyclopropanation of benzyl bromides via C(sp(3))-H bond activation. Chem Commun (Camb). 2014;.
A novel and highly efficient Pd(0)-catalyzed domino reaction to prepare cyclopropane derivatives has been established. The process involves a Heck-type coupling reaction and a C(sp(3))-H bond activation. Preliminary DFT calculations suggest that a four-membered palladacycle intermediate is involved.