Protective Effect of Carvacrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice.

Inflammation

PubMedID: 24577726

Feng X, Jia A. Protective Effect of Carvacrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice. Inflammation. 2014;.
Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-?B and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-a, IL-6 and IL-1ß production.