The Glu298Asp polymorphism in the NOS3 gene and the risk of prostate cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

PubMedID: 24577889

Zhang Y, Jia Q, He Q, Shen J, Yang J, Xue P, Ma M, Xu R, Du L. The Glu298Asp polymorphism in the NOS3 gene and the risk of prostate cancer. Tumour Biol. 2014;.
The Glu298Asp polymorphism in the NOS3 gene has been implicated as a risk factor for prostate cancer. To date, several studies have evaluated the associations between the Glu298Asp polymorphism and prostate cancer risk; however, the results were inconclusive. The aim of the current study was to perform a meta-analysis to investigate the association between the polymorphism and the risk of prostate cancer. A total of 3,206 cases and 3,880 controls from eight case-control studies were included for data synthesis. The overall results suggested no significant association between the polymorphism and the risk of prostate cancer (OR=1.01, 95 % CI=0.92-1.11, p?=?0.83 for Asp/Asp+Glu/Asp vs. Glu/Glu). In the stratified analysis according to ethnicity, no significant associations were observed in Asians and Europeans. The current meta-analysis suggested that the Glu298Asp polymorphism of the NOS3 gene might not contribute to the risk of prostate cancer.