Heps with pep: direct reprogramming into human hepatocytes.

Cell stem cell

PubMedID: 24607399

Vallier L. Heps with pep: direct reprogramming into human hepatocytes. Cell Stem Cell. 2014;14(3):267-9.
The limited supply and expansion capacity of primary human hepatocytes presents major challenges for pharmaceutical applications and development of cell-based therapies for liver diseases. Now in Cell Stem Cell, two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes.