Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma.

Leukemia & lymphoma

PubMedID: 24625328

Favaloro J, Liyadipitiya T, Brown R, Yang S, Suen H, Woodland N, Nassif N, Hart D, Fromm P, Weatherburn C, Gibson J, Ho PJ, Joshua D. Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma. Leuk Lymphoma. 2014;.
ABSTRACT Myeloid derived suppressor cells (MDSC) are a heterogeneous population of cells that have been implicated as inhibitors of lymphopoiesis in patients with malignancies. They have a consensus phenotype of CD33(+)/CD11b(+)/HLA-DR(lo/-) and can be further divided into CD15(+) granulocytic (G-MDSC) and CD14(+) monocytic (M-MDSC) subsets. We characterised MDSC in patients with multiple myeloma (MM) and found a significant increase in G-MDSC in the blood of patients with progressive MM. Flow-sorted MDSC from patients with MM induced the generation of Treg cells. MDSC from both MM patients and aged-matched controls demonstrated a dose dependent inhibition of lymphocyte proliferation in CFSE-tracking experiments. G-CSF administered to induce stem cell mobilisation, caused an increase in the number of MDSC in the peripheral blood of patients with MM and a concentration of these immune-suppressive cells in peripheral blood stem cell collections. MDSCs are likely to cause immune dysfunction in patients with MM.