Prevalence of Chlamydophila pneumoniae Antibodies in Women with Pre-Eclampsia in Lagos, Nigeria.

West African journal of medicine

PubMedID: 23468028

Awoleke JO, Ajayi GO, Adegbola O. Prevalence of Chlamydophila pneumoniae Antibodies in Women with Pre-Eclampsia in Lagos, Nigeria. West Afr J Med. 2013;31(4):253-8.
ABSTRACT BACKGROUND
The precise aetiology of pre-eclampsia has remained unknown. It is still a major contributor to maternal and perinatal morbidity and mortality.

OBJECTIVE
To determine the relationship between pre-eclampsia and immunoglobulin G (IgG) antibodies to Chlamydophila pneumoniae.

METHODS
One hundred and eleven parturients in a tertiary hospital in Lagos, Nigeria comprising 49 women with pre-eclampsia and 62 women without pre-eclampsia were studied.Peripheral blood was obtained for Chlamydophila pneumoniae antibodies which were measured using a solid-phase enzyme-linked immunosorbent assay and maternal diastolic blood pressure, perinatal morbidity and mortality were also assessed.

RESULTS
The cases (N = 49) and controls (N = 62) were evenly matched with respect to age and parity. The women with pre-eclampsia delivered at significantly lower gestational ages than those with normotensive gestations. 66.7% of all the subjects were seropositive for Chlamydophila pneumoniae antibodies. 38 out of the 49 cases (77.6%) were positive for the Chlamydophila pneumoniae antibodies compared with 36 out of the 62 controls (58.1%) [p<0.05].Higher antibody titres were found in parous women with a previous history of pre-eclampsia compared with those without a previous history (p = 0.0308).However, there was no significant association between antibody titres and pregnancy outcome (p >0.05).

CONCLUSION
Results from this study suggest a link between Chlamydophila pneumoniae IgG antibodies and pre-eclampsia. Further prospective studies with larger sizes are needed to verify this association and identify therapeutic options that will effectively prevent the onset or progression of pre-eclampsia.