PPAR-? -- a possible drug target for complicated pregnancies.

British journal of pharmacology

PubMedID: 23186152

McCarthy FP, Delany AC, Kenny LC, Walsh SK. PPAR-? -- a possible drug target for complicated pregnancies. Br J Pharmacol. 2013;168(5):1074-85.
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors expressed in trophoblasts, which regulate both cell differentiation and proliferation. In recent years, evidence has linked PPARs to playing an integral role in pregnancy; specifically, PPAR-ß and PPAR-? have been shown to play an integral role in placentation, with PPAR-? additionally serving to regulate trophoblast differentiation. Recent evidence has shown that PPAR-? expression is altered in many complications of pregnancy such as intrauterine growth restriction (IUGR), preterm birth, pre-clampsia and gestational diabetes. Thus, at present, accumulating evidence from the literature suggests both a pivotal role for PPAR-? in the progression of a healthy pregnancy and the possibility that PPAR-? may act as a therapeutic target in complicated pregnancies. This review aims to provide a succinct and comprehensive assessment of the role of PPAR-? in normal pregnancy and pregnancy complications, and finally its potential as a therapeutic target in the treatment and/or prevention of adverse pregnancy outcomes.