Infectious agents in coronary artery disease: viral infection, aspirin, and gene expression in human coronary smooth muscle cells.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

PubMedID: 9835780

Speir E, Yu ZX, Ferrans VJ. Infectious agents in coronary artery disease: viral infection, aspirin, and gene expression in human coronary smooth muscle cells. Rev Port Cardiol. 1998;17 Suppl 2II33-9.
We and others have observational evidence that human cytomegalovirus (HCMV) may be a pathogen in human atherosclerosis and restenosis. We have experimental evidence that HCMV infects human coronary smooth muscle cells and initiates viral replication. Vascular cells generate reactive oxygen species in response to stress (such as infection or reperfusion) and this leads to increased transcription of atherosclerosis-related cellular and viral genes, and to reactivation of latent HCMV. Finally, we found that aspirin can attenuate this augmented gene transcription via direct and indirect effects.