New 1,2,3-triazole derivatives (ureas, amides, urethanes) with a potential biological interest.

Bollettino chimico farmaceutico

PubMedID: 9859597

Biagi G, Giorgi I, Livi O, Scartoni V, Martinotti E, Calderone V. New 1,2,3-triazole derivatives (ureas, amides, urethanes) with a potential biological interest. Boll Chim Farm. 1998;137(9):350-6.
This paper reports the preparation of three series of 1,2,3-triazole derivatives bearing an ureido substituent (compounds 5a-h), a carboxamido substituent (compounds 6a-f) or an urethane substituent (compounds 7a-l). Some compounds were submitted to in vitro functional tests on guinea-pig isolated intestinal preparations and/or to in vitro antitumor and antiviral screening. The tested compounds showed no activity on guinea-pig ileum, except compound 7g, provided of contracturant properties; similarly, no anticancer or antiviral significant activity was found.