[Physiological role of extracellular proteases and calcium ions in the processes of differentiation and antibiotic production by Streptomyces albogriseolus 444].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR

PubMedID: 9412414

Moncheva PA, Danova ST, Antonova SK, Ivanova IV. [Physiological role of extracellular proteases and calcium ions in the processes of differentiation and antibiotic production by Streptomyces albogriseolus 444]. Antibiot Khimioter. 1997;42(9):14-9.
The extracellular proteolytic activity of Streptomyces albogriseolus 444 was investigated. S. albogriseolus 444 was shown to synthesize an extracellular proteolytic complex with metal-protease and trypsin-like activity defining differentiation of the substrate mycelium to the aerial one as well as the spore formation. The synthesis of the complex proceeded in the absence of the inductor in the medium i.e. constitutively. The complex heterogeneity was confirmed chromatographically. Low concentration of calcium ions (1.5 mM) stimulated the total caseinolytic activity and suppressed the activity of the trypsin-like proteases.