Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

PubMedID: 9332893

van der Velden LA, Schaafsma HE, Manni JJ, Ruiter DJ, Ramaekers FC, Kuijpers W. Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx. Eur Arch Otorhinolaryngol. 1997;254(8):376-83.
The immunohistochemical expression patterns of cytokeratin polypeptides and vimentin were investigated in normal epithelia and squamous cell carcinomas of the larynx with special emphasis on tumor grading. During malignant transformation of epithelial cells, the cytokeratin expression patterns changed, depending on the differentiation grade of the carcinomas. In low-grade carcinomas, the expression patterns were close to those of the normal epithelium. With increasing tumor grade, there was decreased expression of stratification cytokeratins and increased expression of basal cell, simple cell and hyperproliferation-related cytokeratins. Increasing tumor grade was also associated with the expression of vimentin, a cytoskeletal protein of mesenchymal cells. No relationship was found between vimentin expression and the presence of lymph-node metastases.