Correlations between the time-intensity parameters of contrast-enhanced ultrasound and clinical prognosis of hepatocellular carcinoma.

Clinical imaging

PubMedID: 23465984

Yang YL, Yang RJ, Liu X, Liu J, Chao LJ, Duan YY. Correlations between the time-intensity parameters of contrast-enhanced ultrasound and clinical prognosis of hepatocellular carcinoma. Clin Imaging. 2013;37(2):308-12.
PURPOSE
The purpose of the study was to detect the correlation between the time-intensity parameters of contrast-enhanced ultrasound (CEUS) and the clinical prognosis of hepatocellular carcinoma (HCC).

METHODS
A total of 73 HCC patients were analyzed with the time-intensity curve of CEUS. The expression of vascular endothelial factor (VEGF) and CD34 in different differentiation-staged HCC specimens was observed using immunohistochemistry.

RESULTS
A positive correlation was found between the VEGF expression and microvessel density. The time-intensity parameters were not correlated with the HCC size.

CONCLUSIONS
CEUS time-intensity parameters are inducive for assessing the prognosis of HCC with revealed intratumoral microvessel perfusion in different differentiation stages.