Changes in glial fibrillary acidic protein immunoreactivity in the rat facial nucleus following various types of nerve lesions.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

PubMedID: 8950547

Laskawi R, WOLFF JR. Changes in glial fibrillary acidic protein immunoreactivity in the rat facial nucleus following various types of nerve lesions. Eur Arch Otorhinolaryngol. 1997;253(8):475-80.
We report about changes on astrocytes in the facial nucleus of the rat following various types of peripheral nerve lesions. Astrocyte-specific glial fibrillary acidic protein (GFAP) was labeled by immunohistochemistry and served as a marker for these changes. Increased GFAP immunoreactivity was found in the facial nucleus on the lesioned side within 2-3 days after axotomy. This change lasted longer (up to 1 year) when axon regeneration was prevented or delayed by placing a metal clip on the proximal nerve stump. Lesion of the trigeminal nerve prior to axotomy reduced the degree of GFAP immunoreactivity. No side differences were observed after botulinum toxin application.