Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.

British Journal of Psychiatry

PubMedID: 24676965

Crunelle CL, Van Den Brink W, Dom G, Booij J. Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD. Br J Psychiatry. 2014;204(6):486-7.
Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.