Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A.

The Journal of antibiotics

PubMedID: 7730161

Vertuani G, Boggian M, Scatturin A, Ricci M, Meli Balbocchino B, Tuttobello L, Rossi C. Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A. J Antibiot. 1995;48(3):254-60.
The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence of the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.