Primary non-Hodgkin's lymphoma of the vagina. Case report and review of the literature.

Annals of hematology

PubMedID: 7599289

Höffkes HG, Schumann A, Uppenkamp M, Teschendorf C, Schindler AE, Parwaresch R, Brittinger G. Primary non-Hodgkin's lymphoma of the vagina. Case report and review of the literature. Ann Hematol. 1995;70(5):273-6.
The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.