The antitumor activity of the DNA fraction from Mycobacterium bovis BCG (MY-1) for glioblastoma.

The Journal of veterinary medical science / the Japanese Society of Veterinary Science

PubMedID: 7548429

Nakaichi M, Takeuchi A, Shitara N, Takakura K. The antitumor activity of the DNA fraction from Mycobacterium bovis BCG (MY-1) for glioblastoma. J Vet Med Sci. 1995;57(3):583-5.
The antitumor activity of the DNA fraction extracted from Mycobacterium bovis BCG (MY-1) for glioblastoma was investigated in the experimentally produced brain tumor in rats. The tumor-bearing rats were given intralesional injection of 1 mg of MY-1 twice a week for three weeks, and were sacrificed for comparison with those of control rats. The main macroscopic features of the tumors treated with serial injections of MY-1 were cystic and destructive structures, which were histologically characterized by multiple microcysts containing macrophages. Furthermore, infiltration of leukocytes as well as the perivascular cuffing in the marginal area was observed. These findings suggested that the serial injections of MY-1 into the brain tumor have the therapeutic potential for glioblastoma.