Soluble levels of osteopontin in patients with Behcet's disease: association with disease activity and vascular involvement.

Journal of clinical immunology

PubMedID: 23097037

Bassyouni IH, El-Wakd MM, Bassyouni RH. Soluble levels of osteopontin in patients with Behcet's disease: association with disease activity and vascular involvement. J Clin Immunol. 2013;33(2):361-7.
AIM
Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory and autoimmune diseases. We aimed to assess the plasma OPN levels in Behcet's disease (BD) patients and identify potential associations between these levels with disease activity, severity and clinical manifestations with special emphasis on vascular affection.

METHODS
We studied 55 BD patients and 31 age- and gender-matched healthy controls. Demographic, clinical and serological data were prospectively assessed. Activity and severity of BD were assessed using clinical scores and laboratory parameters. Plasma OPN levels were measured using enzyme-linked immunosorbent assay (ELISA).

RESULTS
Plasma OPN levels were significantly higher in patients with BD compared to healthy controls (p?
CONCLUSION
Plasma OPN levels were higher in BD patients than in healthy controls and were found to be associated with disease activity, severity and vascular involvement. To confirm our results we propose that larger scale, multicentre studies with longer evaluation periods are needed.