Toll like receptor 4 D299G associates with disease progression in Caucasian patients with chronic HBV infection: relationship with gender.

Journal of clinical immunology

PubMedID: 23093310

Cussigh A, Fabris C, Fattovich G, Falleti E, Cmet S, Bitetto D, Bignulin E, Toniutto P. Toll like receptor 4 D299G associates with disease progression in Caucasian patients with chronic HBV infection: relationship with gender. J Clin Immunol. 2013;33(2):313-6.
This study aimed to verify whether rs4986790 A?>?G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. A cross-sectional study enrolled 191 Caucasian HBV-positive patients: 28 HBsAg?+?inactive carriers, 121 chronic hepatitis B, 42 HBsAg?+?transplant candidates. A longitudinal study included 94 patients followed-up for a median time of 19.3 years. TLR-4 rs4986790 A/A genotype was carried less frequently in male HBsAg?+?inactive carriers than in males with HBsAg?+?active chronic infection (12/17 Vs 109/121, p?=?0.022). At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A genotype was found to be and independent predictor of liver fibrosis (O.R. 14.8, p?=?0.019). In conclusion, in HBV-positive Caucasian patients, the A/A genotype of the rs4986790 polymorphism may influence a worse outcome of chronic HBV infection, mainly through a synergistic interaction with male gender.