Human papillomavirus, human cytomegalovirus and oncogene C-myc in cervical carcinoma and cervicitis.

Chinese medical journal

PubMedID: 8391967

Huang SL, Liu ZQ, Zhang XN, Li MJ. Human papillomavirus, human cytomegalovirus and oncogene C-myc in cervical carcinoma and cervicitis. Chin Med J. 1993;106(3):208-10.
HPV-16 and HCMV DNA homologous sequence and the status of cellular oncogene C-myc DNA were examined in uterine cervical diseases with dot blot hybridization and Southern hybridization. The results showed a positive rate of 70.8% in HPV-16 and 38.7% in HCMV in cervical carcinoma, and that of 36.7% in HPV-16 and 16.7% in HCMV in cervicitis. C-myc DNA was widely detectable in uterine cervical carcinoma, but the manifestation of translocation, deletion or overexpression in cervical carcinoma was frequent. The value of these findings in the development of cervical carcinoma is discussed.