Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates.

Journal of perinatology : official journal of the California Perinatal Association

PubMedID: 22555780

Polycarpou E, Zachaki S, Papaevangelou V, Tsolia M, Kyriacou A, Kostalos C, Kafetzis D. Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates. J Perinatol. 2013;33(2):141-6.
OBJECTIVE
The objective of this study is to determine the potential effect of oral L-arginine supplementation on intestinal inflammation in very low birth weight (VLBW) neonates, as estimated by faecal calprotectin levels.

STUDY DESIGN
The study enrolled 83 VLBW neonates with birth weight =1500?g and gestational age =34 weeks. In this double-blind study, 40 neonates received daily oral L-arginine supplementation of 1.5?mmol?kg(-1) per day between the 3rd and 28th day of life, and 43 neonates placebo. Stool samples were collected on days 3, 14 and 28, and calprotectin was measured by enzyme-linked immunosorbent assay.

RESULT
Calprotectin values significantly decreased over time in both groups (P=0.032). No difference in faecal calprotectin values was recorded between neonates receiving arginine supplementation and neonates receiving placebo at days 3, 14 and 28.

CONCLUSION
Faecal calprotectin values decrease with increasing postnatal age in VLBW infants, but this is not related to arginine supplementation.