Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study.

Journal of perinatology : official journal of the California Perinatal Association

PubMedID: 22499082

Morris BH, Tyson JE, Stevenson DK, Oh W, Phelps DL, O'Shea TM, McDavid GE, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Kandefer S, Wallace D, Higgins RD. Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study. J Perinatol. 2013;33(2):126-33.
OBJECTIVE
Evaluate the efficacy of phototherapy (PT) devices and the outcomes of extremely premature infants treated with those devices.

STUDY DESIGN
This substudy of the National Institute of Child Health and Human Development Neonatal Research Network PT trial included 1404 infants treated with a single type of PT device during the first 24±12?h of treatment. The absolute (primary outcome) and relative decrease in total serum bilirubin (TSB) and other measures were evaluated. For infants treated with one PT type during the 2-week intervention period (n=1223), adjusted outcomes at discharge and 18 to 22 months corrected age were determined.

RESULT
In the first 24?h, the adjusted absolute (mean (±s.d.)) and relative (%) decrease in TSB (mg?dl(-1)) were: light-emitting diodes (LEDs) -2.2 (±3), -22%; Spotlights -1.7 (±2), -19%; Banks -1.3 (±3), -8%; Blankets -0.8 (±3), -1%; (P<0.0002). Some findings at 18 to 22 months differed between groups.

CONCLUSION
LEDs achieved the greatest initial absolute reduction in TSB but were similar to Spots in the other performance measures. Long-term effects of PT devices in extremely premature infants deserve rigorous evaluation.