Objectively measured physical activity and inflammatory cytokine levels in middle-aged Japanese people.

Preventive medicine

PubMedID: 24732722

Nishida Y, Higaki Y, Taguchi N, Hara M, Nakamura K, Nanri H, Imaizumi T, Sakamoto T, Horita M, Shinchi K, Tanaka K. Objectively measured physical activity and inflammatory cytokine levels in middle-aged Japanese people. Prev Med. 2014;.
OBJECTIVE
Studies using self-reported physical activity (PA) showed that higher PA is associated with lower circulating levels of C-reactive protein, in contrast, studies investigating associations of objective PA and other inflammatory markers are limited. We investigated cross-sectional associations of accelerometer-determined PA with circulating levels of myokine-type inflammatory cytokines in a middle-aged Japanese population.

METHOD
A total of 1,838 individuals (737 men and 1,101 women) aged 40 to 69years participated in the baseline survey of a population-based cohort study in Saga, Japan (2005-2007). Habitual PA was assessed by single-axis accelerometer. Serum interleukin (IL)-4, IL-6, IL-8, IL-15, and tumor necrosis factor (TNF)-a were measured by multiplex enzyme-linked immunosorbent assay. Associations between PA and cytokine levels were assessed by multiple regression analysis and analysis of covariance, with adjustment for potential confounders.

RESULTS
Step count and PA level (PAL) were inversely associated with TNF-a and IL-15 even after adjusting for BMI. Similarly, greater PA indices were also independently associated with lower level of inflammatory cytokine z score an index of overall inflammation.

CONCLUSION
The current results suggest that greater engagement in daily PA may be linked with reduced levels of myokine-type cytokines including IL-15, irrespective of body weight in middle-aged Japanese people.