Immunohistochemical expression of p63, Ki67 and ß-catenin in canine transitional cell carcinoma and polypoid cystitis of the urinary bladder.

Veterinary and comparative oncology

PubMedID: 24758385

Hanazono K, Nishimori T, Fukumoto S, Kawamura Y, Endo Y, Kadosawa T, Uchide T. Immunohistochemical expression of p63, Ki67 and ß-catenin in canine transitional cell carcinoma and polypoid cystitis of the urinary bladder. Vet Comp Oncol. 2014;.
Transitional cell carcinoma (TCC) is a urinary bladder tumour associated with high mortality in dogs. In this study, we investigated the feasibility of using p63, Ki67 or ß-catenin as a clinical marker for predicting biological behaviour and prognosis in canine TCC. Expression levels of these proteins in TCC (n?=?25), polypoid cystitis (n?=?5) and normal urinary bladder (n?=?5) were scored after immunohistochemical staining. The staining scores for p63 (P?