Solid-phase extraction for selective determination of bisphenol A in drinks and fruits by dummy surface molecularly imprinted polymer with direct synthetic method.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

PubMedID: 24761936

Li J, Zhou H, Liu YX, Yan XY, Xu YP, Liu SM. Solid-phase extraction for selective determination of bisphenol A in drinks and fruits by dummy surface molecularly imprinted polymer with direct synthetic method. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;.
A reliable and selective method was developed for the determination of bisphenol A (BPA) in drinks and fruit using dummy surface molecularly imprinted polymer (DSMIP) as a solid-phase extraction-enrichment and separation sorbent coupled with HPLC. Tetrabromobisphenol A (TBBPA), whose structure is similar to BPA was selected as a dummy template molecule. The DSMIP has a higher selectivity for BPA than surface non-imprinted polymer (SNIP) when used as sorbents for solid phase extraction (SPE). Potential factors affecting the extraction efficiency, including conditioning, sample loading, washing and elution and the breakthrough volume were optimized. Under the optimum experimental conditions, the recoveries of BPA in drinks and fruit were in the range from 98% to 105% with relative standard deviations below 7%, and a limit of detection of 3 ng mL(-1). The developed extraction protocol eliminated the effect of template leakage on quantitative analysis and could be applied to the trace determination of BPA in complicated functional samples.