Impact of duration of rupture of membranes on outcomes of premature infants.

Journal of perinatology : official journal of the California Perinatal Association

PubMedID: 24762412

Walker MW, Picklesimer AH, Clark RH, Spitzer AR, Garite TJ. Impact of duration of rupture of membranes on outcomes of premature infants. J Perinatol. 2014;.
Objective:The primary aim of the study was to determine how the risk of adverse outcomes was related to the duration of the latency period and gestational age at birth following preterm premature rupture of the fetal membranes (PPROM).Study Design:Retrospective review of infants discharged from 330 neonatal intensive care units. We defined four subgroups based on gestational age: 23 to 25, 26 to 28, 29 to 31 and 32 to 34 weeks. Each gestational age group was evaluated by duration of ROM: <24?h, 1 to 7 days, 8 to 14 days, 15 to 21 days, 21 to 28 days and >28 days and compared with a referent group (PPROM of >24?h but <7 days).Result:In all, 239?808 non-anomalous infants 23 to 34 weeks' gestational age were identified; 37?233 (15.5%) had rupture of membranes (ROM) >24?h. Compared with a reference group (PPROM of >24?h but <7 days), the risk of mortality for PPROM of 8 to 14, 15 to 21 and 21 to 28 days varied depending on gestational age at birth. Only PPROM >28 days was consistently associated with increased mortality and decreased likelihood of survival without morbidity in all gestational age subgroups.Conclusion:PPROM for >28 days is associated with an increased risk of death and morbidity.Journal of Perinatology advance online publication, 24 April 2014; doi:10.1038/jp.2014.73.