[Preliminary study of contrast-enhanced ultrasound in correlation between muscle perfusion deficits in lower extremity arterial disease and its collateralization].

Zhonghua yi xue za zhi

PubMedID: 24767292

Song Y, Li Y, Lu W, Gao Y. [Preliminary study of contrast-enhanced ultrasound in correlation between muscle perfusion deficits in lower extremity arterial disease and its collateralization]. Zhonghua Yi Xue Za Zhi. 2014;94(7):507-9.
OBJECTIVE
To explore the value of contrast-enhanced ultrasound (CEUS) as a new method in evaluating the correlation between muscle perfusion deficits and collateralization in lower extremity arterial disease (LEAD).

METHODS
Ultrasound contrast agent was injected into peripheral vein of 80 control subjects and 80 LEAD patients. Its appearance in calf muscle was detected by contrast-enhanced ultrasound. Time intensity curves (TIC) and time to peak intensity (TTP) were analyzed. And collateral formation was evaluated by computed tomography angiography (CTA) .

RESULTS
TTP in LEAD group was statistically higher than that in control group (59.1 vs 38.6 s, P < 0.01) . The TTP difference between two investigators who evaluate the row data in a blinded way was 0.29 s and the area under receiver operating characteristic (ROC) curve 0.92. A TTP cutoff at 47.5 s was associated with 91% positive predictive value statistically. TTP in LEAD with bad collateralization was statistically higher than that in LEAD with good collateralization (67.9 vs 50.4 s, P < 0.01) .

CONCLUSION
As a consistent method of evaluating muscle perfusion deficits, CEUS shows a good correlation with the extent of collateral formation in LEAD.