[An association study of six-transmembrane protein of prostate 2 gene with metabolic index and tumour necrosis factor in Uygur population].

Zhonghua nei ke za zhi [Chinese journal of internal medicine]

PubMedID: 24767166

Zu F, Bi Y, Yao X, Wang H, Zhou L, Li N. [An association study of six-transmembrane protein of prostate 2 gene with metabolic index and tumour necrosis factor in Uygur population]. Zhonghua Nei Ke Za Zhi. 2014;53(2):131-4.
OBJECTIVE
To explore the relationship between genetic polymorphisms of six-transmembrane protein of prostate 2 (STAMP2) and metabolic index, TNFa in Xinjiang Uygur population.

METHODS
STAMP2 gene functional regions were sequenced in Uygur Xinjiang population diagnosed as metabolic syndrome. Patients were divided into the following three groups by their TNFa concentration: the high level group (TNFa = 7.95 µg/L, n = 313), the moderate level group (TNFa >5.34- < 7.95 µg/L, n = 268) and the low level group ( = 5.34 µg/L, n = 313) . The selected representative variations were genotyped by TaqMan-PCR in 894 Uygur individuals. The association of the genetic variations of STAMP2 gene with metabolic index and TNFa was analyzed.

RESULTS
Three representative variations were genotyped, including rs8122, rs1981529 and rs34741656. The genotype distribution and allele frequencies of rs8122 and rs1981529 were statistically different among the three groups (P < 0.05), while no difference was observed with rs34741656 (P > 0.05). By ANOVA analysis, statistical difference was showed between the rs1981529 polymorphism AA and AG in the concentration of TNFa (P < 0.05) . None of the polymorphisms was significantly associated with TC, HDL-C, LDL-C and TG (P > 0.05).

CONCLUSION
Two STAMP2 gene polymorphisms, rs8122 and rs1981529 are associated with the concentration of TNFa in Xinjiang Uygur population.