Metals in Protein-Protein Interfaces.

Annual review of biophysics

PubMedID: 24773016

Song WJ, Sontz PA, Ambroggio XI, Tezcan FA. Metals in Protein-Protein Interfaces. Annu Rev Biophys. 2014;.
From the catalytic reactions that sustain the global oxygen, nitrogen, and carbon cycles to the stabilization of DNA processing proteins, transition metal ions and metallocofactors play key roles in biology. Although the exquisite interplay between metal ions and protein scaffolds has been studied extensively, the fact that the biological roles of the metals often stem from their placement in the interfaces between proteins and protein subunits is not always recognized. Interfacial metal ions stabilize permanent or transient protein-protein interactions, enable protein complexes involved in cellular signaling to adopt distinct conformations in response to environmental stimuli, and catalyze challenging chemical reactions that are uniquely performed by multisubunit protein complexes. This review provides a structural survey of transition metal ions and metallocofactors found in protein-protein interfaces, along with a series of selected examples that illustrate their diverse biological utility and significance. Expected final online publication date for the Annual Review of Biophysics Volume 43 is May 06, 2014. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.