Th17 cells are associated with the Th1/Th2-cell balance during Echinococcus multilocularis infection.

Molecular medicine reports

PubMedID: 24789110

Ma X, Wang L, Zhao H, Pang N, Zhang F, Jiang T, Liu X, Mamuti W, Wen H, Ding J. Th17 cells are associated with the Th1/Th2-cell balance during Echinococcus multilocularis infection. Mol Med Rep. 2014;.
The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T-helper (Th) 17-cytokine, interleukin 17 (IL-17), was observed using immunohistochemical staining, and levels of cytokines, including IL-17, transforming growth factor ß1 (TGF-ß1), IL-6, interferon ? (IFN-?) and IL-4, were assessed using ELISA at different stages of infection. IL-17 expression occurred in hepatic cells at 1 month post-infection, reached a maximum at 3 months post-infection and then decreased gradually. Compared with the uninfected control, levels of the cytokines IL-17, TGF-ß1, IL-6, IFN-? and IL-4 exhibited different dynamic patterns when infected with Em. In the immune response during the whole infection period, Th17 cells play an important role by secreting IL-17, which may be involved in the Th1/Th2-cell balance during the immune response. Th17 cells are associated with immunopathology in Em infection.