[Clinico-hematological evaluation of 57 patients undergoing antiaggregant treatment with indobufen].

Recenti progressi in medicina

PubMedID: 2236828

Andriani A, Mosiello G, Chiappetta MG, Gregori G, Rinaldi P. [Clinico-hematological evaluation of 57 patients undergoing antiaggregant treatment with indobufen]. Recenti Prog Med. 1990;81(1):49-53.
A long-term administration of Indobufen, 400 mg daily, was evaluated in 57 patients with cardiovascular diseases. Aggregation waves induced by ADP, collagen and epinephrine showed a significant and persistent inhibition of platelet function. Minor side effects were observed and in 6 patients the drug was withdrawn: 4 patients began to experience gastric troubles, 1 patient had positive occult test for blood, 1 patient developed an allergic rush. Clinical evaluation and platelet aggregation study before starting indobufen and during the follow up period seem to be useful in the evaluation of effectiveness, safety, compliance and suitable daily dose.