[Emerging notions about the microenvironmental control of tumor growth and dissemination].

Medecine sciences : M/S

PubMedID: 24801029

Provot S. [Emerging notions about the microenvironmental control of tumor growth and dissemination]. Med Sci (Paris). 2014;30(4):366-71.
In spite of a good understanding of the cellular and molecular mechanisms responsible for neoplastic transformation, most cancer therapies remain partially effective and transient. Recent studies established the importance of the tumor microenvironment in tumor growth and dissemination, and in the resistance to antitumor therapies. This review summarizes our current knowledge of the local and systemic effects, sometimes surprising, which result from interactions between neoplastic cancer cells and their microenvironment.