[Non-Hodgkin lymphoma in patients with an HIV-infection].

Nederlands tijdschrift voor geneeskunde

PubMedID: 2062408

van der Ende ME, Michiels JJ, Mulder AH, Rothbarth PH. [Non-Hodgkin lymphoma in patients with an HIV-infection]. Ned Tijdschr Geneeskd. 1991;135(23):1045-8.
In the period 1985-1990, 111 patients with AIDS were treated in the University Hospital Rotterdam-Dijkzigt. In 8 out of 111 patients malignant non-Hodgkin lymphoma developed. The unusual and bizarre representation is highlighted by several clinical histories and a review of literature. HIV-related non-Hodgkin lymphoma is characterized by widespread extranodal disease, often at unusual sites, and high grade B-cell malignancy. The therapeutic outcome and survival in these cases has been disappointing. Prognosis is better for patients without a prior AIDS diagnosis, higher total CD4 cell counts, good performance score and absence of an extranodal site of disease. Treatment should be tailored to individual patients based upon a variety of prognostic features.