Thrombomodulin Biology and potential cardiovascular applications.

Trends in cardiovascular medicine

PubMedID: 21239288

Dittman WA. Thrombomodulin Biology and potential cardiovascular applications. Trends Cardiovasc Med. 1991;1(8):331-6.
Thrombomodulin on endothelial surfaces is the major cofactor for the activation of the anticoagulant protein C by thrombin. Recent studies of the structure and regulation of thrombomodulin provide important clues as to its mechanism of action. These studies should enable the rational use of thrombomodulin as a therapeutic agent to inhibit coagulation either by infusion of thrombomodulin or its derivatives, or by pharmacologic alteration of cellular levels.