[The effect of the synergistic action of enterotoxin on the specific protective complex of Shigella sonnei].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii

PubMedID: 1789032

Korneeva SA, Kovalevskaia IL. [The effect of the synergistic action of enterotoxin on the specific protective complex of Shigella sonnei]. Zh Mikrobiol Epidemiol Immunobiol. 1991;(12):38-41.
The study has first established that enterotoxin enhances the protective potency of S. sonnei specific protective complex. This effect has been revealed both in experiments of the oral immunization of mice and in experiments of the conjunctival immunization of guinea pigs and depends on the dose of enterotoxin used in the experiment. The increase of protection has a specific character. These observations open prospects for further enhancement for the protective properties of S. sonnei specific protective complex, which should be taken into consideration in developing the vaccinal preparation.