Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis.

Progress in neuro-psychopharmacology & biological psychiatry

PubMedID: 23228461

Ayesa-Arriola R, Pérez-Iglesias R, Rodríguez-Sánchez JM, Pardo-García G, Tabares-Seisdedos R, Ayuso-Mateos JL, Vázquez-Barquero JL, Crespo-Facorro B. Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis. Prog Neuropsychopharmacol Biol Psychiatry. 2013;4323-8.
BACKGROUND
Neurocognitive impairment is a core component of schizophrenia. However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients.

METHODS
Neurocognitive performance was analyzed in a cohort of 146 patients 3 years after a first episode non-affective psychosis. Subgroups, impaired vs. unimpaired, were compared on baseline clinical, neuropsychological, premorbid and sociodemographic characteristics.

RESULTS
Fifty-nine percent of participants presented general neurocognitive impairment and regression analyses demonstrated that clinical and sociodemographic characteristics were not predictive variables. A model composed of premorbid IQ, verbal memory and motor dexterity correctly classified 79.6% of the individuals.

CONCLUSIONS
The present study gives information on frequency and neurocognitive profile of subtypes of patients showing impairment. Our results suggest general neurocognitive impairment is a trait dimension of the disorder related to specific cognitive dysfunctions.