Kinin generation following methacholine nasal airway challenge of non-allergic subjects.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

PubMedID: 1418940

Baumgarten CR, Niemz W, Kunkel G. Kinin generation following methacholine nasal airway challenge of non-allergic subjects. Eur Arch Otorhinolaryngol. 1992;249(6):318-21.
Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.