Carcinoma of the ampulla of vater after curative treatment for Hodgkin's disease.

American Journal of Gastroenterology

PubMedID: 1539576

Boyle JM, Schreiber H, Rao S, Berman JH. Carcinoma of the ampulla of vater after curative treatment for Hodgkin's disease. Am J Gastroenterol. 1992;87(3):372-4.
A 43-yr-old woman developed carcinoma of the ampulla of Vater 20 yr after being successfully treated for Hodgkin's disease with radiotherapy and chemotherapy. Conditions related to the chronic effect of radiation, such as narrowing and fibrosis of abdominal tissue, hampered her diagnosis and treatment. After a total pancreatectomy to remove the carcinoma, the patient recovered. However, 15 months later, she developed severe digestive disturbances, adrenal insufficiency, pulmonary emboli, and vasculitis. She died the next month of sepsis and adult respiratory distress syndrome. Although her complications probably were related to residual effects from therapy and surgery, she had no clinical evidence of tumor recurrence.