Long-range attraction and molecular rearrangements in receptor-ligand interactions.

Science

PubMedID: 1542789

Leckband DE, Israelachvili JN, Schmitt FJ, Knoll W. Long-range attraction and molecular rearrangements in receptor-ligand interactions. Science. 1992;255(5050):1419-21.
A surface force apparatus was used to measure a long-range attractive protein-ligand force at separations D less than 85 angstroms. This force may effectively "steer" ligand trajectories, resulting in a greater than 27-fold enhancement of the association rate. A much stronger specific attraction is measured at contact (D less than 4 angstroms). A sevenfold increase in intermembrane adhesion resulted from increased lateral mobility of the receptors and molecular rearrangements in membranes above the solid-fluid transition temperature.