Engineered Proteins for Bioelectrochemistry.

Annual review of analytical chemistry (Palo Alto, Calif.)

PubMedID: 24818813

Akram MS, Rehman JU, Hall EA. Engineered Proteins for Bioelectrochemistry. Annu Rev Anal Chem (Palo Alto Calif). 2014;.
It is only in the past two decades that excellent protein engineering tools have begun to meet parallel advances in materials chemistry, nanofabrication, and electronics. This is revealing scenarios from which synthetic enzymes can emerge, which were previously impossible, as well as interfaces with novel electrode materials. That means the control of the protein structure, electron transport pathway, and electrode surface can usher us into a new era of bioelectrochemistry. This article reviews the principle of electron transfer (ET) and considers how its application at the electrode, within the protein, and at a redox group is directing key advances in the understanding of protein structure to create systems that exhibit better efficiency and unique bioelectrochemistry. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 7 is June 15, 2014. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.